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Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Identifieur interne : 000C43 ( Main/Exploration ); précédent : 000C42; suivant : 000C44

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Auteurs : Xiaoxv Dong [République populaire de Chine] ; Jing Fu [République populaire de Chine] ; Xingbin Yin [République populaire de Chine] ; Sali Cao [République populaire de Chine] ; Xuechun Li [République populaire de Chine] ; Longfei Lin [République populaire de Chine] ; Jian Ni [République populaire de Chine, Niger]

Source :

Phytotherapy Research [ 0951-418X ] ; 2016-08.

RBID : ISTEX:F2AFB36389C7E085A25C8E9A011DFC5C7FA28F07

Abstract

Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000 years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with long‐term use. Pharmacokinetic studies have demonstrated that emodin has poor oral bioavailability in rats because of its extensive glucuronidation. This review aims to comprehensively summarize the pharmacology, toxicity and pharmacokinetics of emodin reported to date with an emphasis on its biological properties and mechanisms of action. Copyright © 2016 John Wiley & Sons, Ltd.

Url:

https://api.istex.fr/ark:/67375/WNG-SJWZX3Z4-Q/fulltext.pdf

DOI: 10.1002/ptr.5631

Affiliations:

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Le document en format XML

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<front><div type="abstract">Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000 years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with long‐term use. Pharmacokinetic studies have demonstrated that emodin has poor oral bioavailability in rats because of its extensive glucuronidation. This review aims to comprehensively summarize the pharmacology, toxicity and pharmacokinetics of emodin reported to date with an emphasis on its biological properties and mechanisms of action. Copyright © 2016 John Wiley & Sons, Ltd.</div>
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Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

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Abstract

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